No, the Weaning can only be used when the baseline is at the default setting (B/Blue).
Since Weaning mode restricts movement on the baseline, it would be counterproductive to SNOO's benefits of having the baseline set a higher level. In fact, we recommend that parents who have SNOO starting on a higher baseline change it back to blue baseline two weeks prior to starting Weaning (to get baby used to less and less motion).